Interaction of the selective progesterone 16a, 17a-cyclohex-3'-enoprogesterone agonist with the rat uterus progesterone receptor
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چکیده
منابع مشابه
Progesterone regulation of the progesterone receptor in rat gonadotropes.
For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms. Nuclear PR-immunoreactivity (PR-IR) in gonadotropes, identified by dual immunofluorescenc...
متن کاملProgesterone receptor mRNA levels during pregnancy, labor, lactation and the estrous cycle in rat uterus.
Progesterone plays important roles in the regulation of female reproduction. In this study, progesterone receptor (PR) mRNA levels in rat uterus during pregnancy, labor, lactation and the estrous cycle were examined by competitive RT-PCR. During pregnancy and lactation, PR mRNA levels had decreased on day 20 of pregnancy (P20) and P21 compared with P15 but increased during labor. After a declin...
متن کاملTissue- and hormone- dependent progesterone receptor distribution in the rat uterus
BACKGROUND Estradiol (E2) and progesterone (P) are well known regulators of progesterone receptor (PR) expression in the rat uterus. However, it is not known which receptor subtypes are involved. Little knowledge exist about possible differences in PR regulation through ERalpha or ERbeta, and whether the PR subtypes are differently regulated depending on ER type bound. Thus, in the present stud...
متن کاملEffects of progesterone, estrogen, and androgen on progesterone receptor binding in hen oviduct uterus (shell gland).
The specific [3H] progesterone binding per milligram of protein of the cytosolic fraction of the hen uterus was found to have decreased at 1 and 4 h after the injection of progesterone (P4), but increased at 4 and 8 h after the injection of estradiol-17 beta (E2), and at 1 and 4 h after the injection of testosterone (T). The equilibrium dissociation constant obtained by Scatchard analysis was n...
متن کاملMessenger RNA for progesterone receptor isoforms in the late-gestation rat uterus.
The progesterone receptor (PR) has three isoforms, PR-A, PR-B, and PR-C, which have different physiological effects. PR-A may inhibit PR-B-mediated transcription. Parturition requires withdrawal of progesterone (P4). This could occur through decreased P4 concentrations and/or a change in PR isoforms to diminish the effect of P4. We measured mRNA for PR isoforms in rat uterine tissues through la...
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ژورنال
عنوان ژورنال: Problems of Endocrinology
سال: 1998
ISSN: 2308-1430,0375-9660
DOI: 10.14341/probl199844137-40